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In animal scientific studies, the median lethal dose (LD50) of modafinil varies among species and relies on the route of administration. In mice and rats, the LD50 is around 1250 mg/kg if administered by means of an injection, but the oral LD50 for rats is 3400 mg/kg.
itraconazole will boost the amount or result of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
modafinil will boost the amount or influence of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. Contraindicated. Sturdy or average CYP2C19 inhibitors may possibly improve mavacamten systemic publicity, causing heart failure resulting from systolic dysfunction.
FYCOMPA is a prescription drugs utilised alone or with other medicines to treat partial-onset seizures with or devoid of secondarily generalized seizures in individuals with epilepsy aged four and more mature and with other medicines to deal with Most important generalized tonic-clonic seizures in those with epilepsy aged 12 and older. Crucial SAFETY Information and facts
Shantia shares aspects regarding the conversation she and her medical doctor experienced about starting off FYCOMPA to treat her seizures.
rifabutin will decrease the level or impact of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
Avoid or substitute A further drug for these remedies when feasible. Appraise for loss of therapeutic impact if medication must be coadministered. Change dose In line with prescribing details if required.
Keep track of Intently (1)crofelemer improves amounts of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Crofelemer has the likely to inhibit CYP3A4 at concentrations anticipated in the gut; unlikely to inhibit systemically because minimally absorbed.
200mg Modafinil: The king of nootropics! 200mg Modafinil is the gold regular In relation to crushing cognition. Numerous people practical experience twelve+ hrs of laser-like emphasis at this dosage. Slight Unintended effects not widespread, but some end users encounter dehydration, headaches, or sleeplessness.
Keep an eye on more information Carefully (1)voriconazole will boost the level or influence of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Provigil will never remedy obstructive slumber apnea or handle its underlying will cause. Stick to your doctor's Recommendations about all your other remedies for this disorder.
Avoid or substitute An additional drug for these prescription drugs when probable. Appraise for loss of therapeutic impact if medication has to be coadministered.
cannabidiol will boost the amount or effect of modafinil by influencing hepatic enzyme CYP2C19 metabolism. Modify Therapy/Watch Carefully. Think about reducing the dose of delicate CYP2C19 substrates, as clinically acceptable, when coadministered with cannabidiol.